BiochemistrybioRxiv
Development of LRRK2 designed ankyrin-repeat proteins
V. Dederer, M. Sanz Murillo, E. P. Karasmanis…·S. Knapp
This study develops a high-affinity DARPin that binds to LRRK2's WD40 domain, improving structural analysis and revealing its role in disrupting LRRK2 filaments and Rab8A phosphorylation.
DOI 10.1016/j.jbc.2024.107469