Emergent chirality in active solid rotation of pancreas spheres
T. H. Tan, A. Amiri, I. Seijo-Barandiaran, M. F. Staddon, A. Materne, S. Tomas, C. Duclut, M. Popovic, A. Grapin-Botton, F. Jülicher
This study investigates how 3D geometry and topology influence collective cell dynamics in pancreatic organoids, revealing spontaneous chiral symmetry breaking through topological defects in traction forces.
bioRxiv · Sep 29, 2022Biophysics