M. F. Staddon

Mechanical positive feedback and biochemical negative feedback combine to generate complex contractile oscillations in cytokinesis

The paper shows that mechanical and biochemical feedbacks combine to create complex contractile oscillations during cytokinesis.

Tight junctions regulate lumen morphology via hydrostatic pressure and junctional tension

This study investigates how tight junctions regulate lumen morphology through hydrostatic pressure and junctional tension in MDCKII cysts.

Emergent chirality in active solid rotation of pancreas spheres

This study investigates how 3D geometry and topology influence collective cell dynamics in pancreatic organoids, revealing spontaneous chiral symmetry breaking through topological defects in traction forces.

Pulsatile contractions and pattern formation in excitable actomyosin cortex

This study develops a reaction-diffusion model to investigate how mechanochemical feedback in the actin cortex generates pulsatile contractions and pattern formation.

Mechanosensitive junction remodelling promotes robust epithelial morphogenesis

This study shows that mechanosensitive tension remodelling of epithelial junctions enables robust shape changes through a ratcheting mechanism, using optogenetic control and a modified vertex model.

RhoA mediates epithelial cell shape changes via mechanosensitive endocytosis

This study shows RhoA controls epithelial cell shape through mechanosensitive endocytosis, requiring formin and dynamin, and develops a vertex model to explain junction remodeling.

Tissue Fluidity Promotes Epithelial Wound Healing

The paper shows that reducing junctional tension increases tissue fluidity, which accelerates wound healing in epithelial tissues.

Force localization modes in dynamic epithelial colonies

The paper introduces an Active Adherent Vertex Model to study how cell-scale dynamics influence traction stress distribution in epithelial colonies.