Author

F. Klemm

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

A. Salamero-Boix· 1 shared A. Schaeffer· 1 shared B. T. Elie· 1 shared J. A. Joyce· 1 shared J. Zinke· 1 shared K. H. Plate· 1 shared K. Niesel· 1 shared L. Sevenich· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. Salamero-Boix

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1 paper

Recent·Most cited

Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis

F. Klemm, A. Schaeffer, A. Salamero-Boix, T. Alekseeva, M. Schulz, K. Niesel, R. R. Maas, M. Groth, B. T. Elie, R. L. Bowman, M. E. Hegi, R. T. Daniel, P. S. Zeiner, J. Zinke, P. N. Harter, , L. Sevenich

The paper shows that blocking CSF1R in brain metastases initially reduces tumor growth but is ineffective in established tumors due to compensatory macrophage activation, which is overcome by combining CSF1R and STAT5 inhibition.

bioRxiv · Jun 7, 2021Cancer Biology