γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects
N. L. de Vries, J. v. d. Haar, V. Veninga, M. Chalabi, M. E. Ijsselsteijn, M. v. d. Ploeg, J. v. d. Bulk, D. Ruano, J. B. Haanen, T. N. Schumacher, L. F. A. Wessels, F. Koning, N. F. C. C. de Miranda, E. E. Voest
This study shows that γδ T cells, not CD8+ T cells, mediate immune checkpoint blockade efficacy in HLA class I-negative, MMR-d colon cancers.
bioRxiv · Oct 14, 2021 · PreprintCancer Biology