Author

J. B. Haanen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Assay:flow cytometry· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

D. Amsen· 2 shared K. Monkhorst· 2 shared M. C. Wolkers· 2 shared M. M. van Loenen· 2 shared R. M. Spaapen· 2 shared A. Bex· 1 shared A. Guislain· 1 shared B. P. Nicolet· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

D. Amsen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

N. L. de Vries, J. v. d. Haar, V. Veninga, M. Chalabi, M. E. Ijsselsteijn, M. v. d. Ploeg, J. v. d. Bulk, D. Ruano, J. B. Haanen, T. N. Schumacher, L. F. A. Wessels, F. Koning, N. F. C. C. de Miranda, E. E. Voest

This study shows that γδ T cells, not CD8+ T cells, mediate immune checkpoint blockade efficacy in HLA class I-negative, MMR-d colon cancers.

bioRxiv · Oct 14, 2021 · PreprintCancer Biology

T cells expanded from renal cell carcinoma are tumor-reactive but fail to produce IFN-γ, TNF-α or IL-2

S. D. van Asten, R. d. Groot, M. M. van Loenen, J. d. Jong, K. Monkhorst, J. B. Haanen, D. Amsen, A. Bex, R. M. Spaapen, M. C. Wolkers

The paper examines TILs from RCC patients, finding that while some are tumor-reactive, they fail to produce key cytokines in response to autologous tumors.

bioRxiv · May 17, 2020 · PreprintImmunology

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

R. de Groot, M. M. van Loenen, A. Guislain, B. P. Nicolet, J. J. Freen-van Heeren, O. Verhagen, M. M. van den Heuvel, J. de Jong, P. Burger, E. van der Schoot, R. M. Spaapen, D. Amsen, J. B. Haanen, K. Monkhorst, K. J. Hartemink, M. C. Wolkers

The paper isolates and expands tumor-reactive T cells from NSCLC tumors, finding that polyfunctional T cells correlate with immune-engaged T cell profiles and tumor reactivity.

bioRxiv · Jun 8, 2019Immunology