Author

F. M. Ashcroft

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Assay:electrophysiology· 2 Assay:fluorescence / live-cell microscopy· 2 Approach:microscopy & imaging analysis· 2 Approach:biophysical modeling· 1 Organism:human· 1

Frequent Co-Authors

N. Vedovato· 2 shared P. J. Stansfeld· 2 shared S. Usher· 2 shared T. Pipatpolkai· 2 shared M. C. Puljung· 1 shared M. Puljung· 1 shared P. Proks· 1 shared R. A. Corey· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

N. Vedovato

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Author profile →

4 papers

Recent·Most cited

The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel

T. Pipatpolkai, S. G. Usher, N. Vedovato, F. M. Ashcroft, P. J. Stansfeld

This study shows that PIP2 and ATP interact allosterically at the KATP channel through shared residue K39, with PIP2 overriding ATP inhibition in the presence of both ligands.

bioRxiv · May 6, 2021Biochemistry

Evaluating Inositol phospholipid interactions with Inward Rectifier Potassium Channels and characterising their role in Disease

T. Pipatpolkai, R. A. Corey, P. Proks, F. M. Ashcroft, P. J. Stansfeld

This study uses molecular dynamics to evaluate phosphoinositide interactions with hKir channels and shows how mutations affect PIP2 binding affinity.

bioRxiv · Sep 3, 2020Biochemistry

Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry

S. Usher, F. M. Ashcroft, M. C. Puljung

The paper investigates how nucleotides inhibit pancreatic KATP channels using patch-clamp fluorometry, revealing SUR1's dual role in nucleotide binding and stabilizing the closed state.

bioRxiv · Oct 15, 2019Biophysics

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

M. Puljung, N. Vedovato, S. Usher, F. M. Ashcroft

The paper investigates the role of NBS2 in KATP channel gating using FRET to measure nucleotide binding and mutation analysis.

bioRxiv · Feb 12, 2019Biophysics