Author

S. G. Usher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

F. M. Ashcroft· 1 shared H. C. Chua· 1 shared K. Schott· 1 shared N. Vedovato· 1 shared O. Serra· 1 shared P. J. Stansfeld· 1 shared S. Pless· 1 shared T. Pipatpolkai· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperBiochemistry

F. M. Ashcroft

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2 papers

Recent·Most cited

Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore module

K. Schott, S. G. Usher, O. Serra, V. Carnevale, S. Pless, H. C. Chua

This paper identifies a hidden drug binding site in NALCN by unplugging its lateral fenestrations and shows that 2-APB and phenytoin access the pore through distinct pathways.

bioRxiv · Apr 12, 2023 · PreprintPharmacology & Toxicology

The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel

T. Pipatpolkai, S. G. Usher, N. Vedovato, F. M. Ashcroft, P. J. Stansfeld

This study shows that PIP2 and ATP interact allosterically at the KATP channel through shared residue K39, with PIP2 overriding ATP inhibition in the presence of both ligands.

bioRxiv · May 6, 2021Biochemistry