T. Pipatpolkai

This study reports cryo-EM structures of NhaA and NHE9 with lipid binding at the dimer interface, showing PI(3,5)P2 stabilizes NHE9 oligomerization and enhances activity.

This study shows that PIP2 and ATP interact allosterically at the KATP channel through shared residue K39, with PIP2 overriding ATP inhibition in the presence of both ligands.

This study uses molecular dynamics simulations to show PIP2 promotes a conformational transition in TREK-1 channels from down to up states.

This study develops a method to determine protein-lipid binding affinities from MD simulations and validates it against experimental and computational methods.

This study uses molecular dynamics to evaluate phosphoinositide interactions with hKir channels and shows how mutations affect PIP2 binding affinity.