The route of vaccine administration determines whether blood neutrophils undergo long-term phenotypic modifications
Y. Feraoun, C. Joly, J.-L. Palgen, N. Tchitchek, E. Marcos-Lopez, N. Dereuddre-Bosquet, A.-S. Gallouet, V. Contreras, Y. Levy, F. Martinon, R. Le Grand, A.-S. Beignon
This study shows that subcutaneous vaccine administration leads to long-term phenotypic changes in blood neutrophils, unlike intradermal administration, highlighting the role of delivery route in immune training.
bioRxiv · Oct 26, 2021Immunology