V. Contreras

Multimodal mucosal and systemic immune characterization of a novel non-human primate trachoma model highlights the critical role of local immunity during acute phase disease

This study develops a non-human primate model of acute trachoma and characterizes the local immune response kinetics following Chlamydia trachomatis infection.

ACE2 mimetic antibody potently neutralizes all SARS-CoV-2 variants and fully protects in XBB.1.5 challenged monkeys

A novel adjuvant formulation induces robust Th1/Th17 memory and mucosal recall responses in Non-Human Primates

This paper develops a novel liposomal adjuvant, CAF(R)10b, that induces robust Th1/Th17 memory and mucosal recall responses in non-human primates.

Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates.

This study examines how SARS-CoV-2 variants of concern affect viral dynamics in non-human primates, finding that most variants escape immune responses, with delta and omicron showing significant differences in viral production rates.

The route of vaccine administration determines whether blood neutrophils undergo long-term phenotypic modifications

This study shows that subcutaneous vaccine administration leads to long-term phenotypic changes in blood neutrophils, unlike intradermal administration, highlighting the role of delivery route in immune training.

Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects Macaques from infection

This study develops a synthetic SARS-CoV-2 S glycoprotein virus-like particle vaccine that protects macaques from infection through strong antibody and T cell responses.

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

This paper develops a two-component spike nanoparticle vaccine that protects macaques from SARS-CoV-2 infection by inducing strong neutralizing antibodies and reducing viral replication.

Targeting MOG to skin macrophages prevents EAE in macaques through TGFβ-induced peripheral tolerance

This paper shows that targeting MOG to skin macrophages via a fusion protein prevents EAE in macaques by inducing TGFβ-mediated peripheral tolerance.