Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment
F. P. M. Rowdo, G. Xiao, G. F. Khramtsova, J. Nguyen, O. Olopade, R. Martini, B. Stonaker, R. Boateng, J. K. Oppong, E. K. Adjei, B. Awuah, I. Kyei, F. S. Aitpillah, M. O. Adinku, K. Ankomah, , J. Bargonetti
This study shows that tumor organoids with mutant p53 are more sensitive to the combination of PARP inhibitor and temozolomide than those with wild-type p53.
bioRxiv · Jun 22, 2023Cancer Biology