G. Xiao

A Lung Cancer Mouse Model Database

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

Liver cancer initiation is dependent on metabolic zonation but decoupled from premalignant clonal expansion

This study shows that liver cancer initiation depends on metabolic zonation but is not linked to premalignant clonal expansion.

High-sensitivity whole-genome recovery of single viral species in environmental samples

This paper develops a method to recover complete viral genomes from environmental samples with high sensitivity, achieving 100% recovery of a spiked-in virus and 99.4% for a larger virus.

Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2

This study develops nanoPDLIM2, a PDLIM2-expressing nanoparticle, which enhances PD-1 blockade and chemotherapy efficacy in lung cancer by reactivating tumor immunity and reducing drug resistance.

Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment

This study shows that tumor organoids with mutant p53 are more sensitive to the combination of PARP inhibitor and temozolomide than those with wild-type p53.

Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies

This study identifies a unique vulnerability in B-cell malignancies where GSK3β inhibitors disrupt β-catenin-Ikaros complexes, leading to MYC repression and cell death.

Kindlin-2 inhibits TNF/NF-kB-caspase 8 pathway in hepatocytes to maintain liver development and function

This study shows Kindlin-2 inhibits the TNF/NF-kB-caspase 8 pathway in hepatocytes, preventing liver fibrosis and dysfunction, and identifies it as a potential therapeutic target for liver diseases.

A Deep Learning Approach for Histology-Based Nuclei Segmentation and Tumor Microenvironment Characterization

This study introduces HD-Yolo, a deep learning method for faster and more accurate nuclei segmentation and tumor microenvironment quantification in whole-slide images.

The small cell lung cancer neuroendocrine transdifferentiation explorer

This study curates genes associated with NE transdifferentiation in SCLC and compares transcriptomic changes across multiple datasets to create a web tool for exploring NE transdifferentiation in SCLC and NBL.

The Piks allele of the NLR immune receptor Pik breaks the recognition of AvrPik effectors of the rice blast fungus

The paper characterizes the Piks allele of the rice immune receptor Pik, showing it does not recognize known AvrPik effectors of the rice blast fungus, suggesting a novel recognition mechanism.

Real-time denoising of fluorescence time-lapse imaging enables high-sensitivity observations of biological dynamics beyond the shot-noise limit

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.

Spinning Disk Multifocal Microscopy for Dynamic Arbitrarily Shaped Surface Imaging at Centimetre Scale and Micrometre Resolution

This paper introduces Spinning Disk Multifocal Microscopy (SDiM) for high-speed, high-resolution imaging of large biological surfaces, demonstrating its application in cortical and immune cell studies.

Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

Rapid deep widefield neuron finder driven by virtual calcium imaging data

The paper introduces DeepWonder, a deep learning tool for rapid and accurate neuron detection in widefield calcium imaging data, achieving faster processing and improved signal-to-background ratio compared to traditional methods.

Screening and Identification of Lujo Virus Entry Inhibitors from an FDA-Approved Drugs Library

This study identifies three FDA-approved drugs that inhibit Lujo virus entry by targeting the envelope glycoprotein's transmembrane domain and calcium channels.

Mechanism through which retrocyclin targets flavivirus multiplication

This study investigates how retrocyclin-101 inhibits flavivirus infection by targeting the NS2B-NS3 protease and the DE loop of the E glycoprotein.

Screening and Identification of Lassa Virus Endonuclease-targeting Inhibitors from a Fragment-based Drug Development Library

The paper screens a fragment-based library to identify inhibitors of Lassa virus endonuclease, finding two benzotriazole compounds that inhibit viral minigenome activity and show synergistic antiviral effects.

Screening of Botanical Drugs against SARS-CoV-2 Entry

This study screens botanical drugs against SARS-CoV-2 entry and identifies four compounds that inhibit viral entry and show synergy with remdesivir.

Identification of residues in Lassa virus glycoprotein 1 involved in receptor switch

This study identifies four residues in Lassa virus GP1 critical for receptor switch to LAMP1, showing their impact on binding affinity and infectivity.

Effects of N-linked glycan of Lassa Virus Envelope Glycoprotein on the Immune Response

This study evaluates how N-linked glycans on Lassa virus GPC affect immune response, finding that glycan deletion enhances effector T cell proportions and antibody titers, suggesting potential for vaccine design.

RNAi screening reveals requirement for PDGFRβ in JEV infection.

This study identifies PDGFRβ as a host factor required for JEV infection and shows that imatinib can protect against JEV by reducing viral load and histopathology.

Functional Characterization of a Lassa Virus Fusion Inhibitors Adaptive Mutant

This study characterizes an adaptive mutant of Lassa virus glycoprotein complex that confers resistance to fusion inhibitors and alters viral fusion properties.

Structural basis for repurpose and design of nucleoside drugs for treating COVID-19

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

The allelic rice immune receptor Pikh confers extended resistance to strains of the blast fungus through a single polymorphism in the effector binding interface

This paper identifies a single amino acid change in the Pikh allele of a rice immune receptor that extends resistance to multiple strains of the blast fungus through enhanced effector binding.

Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

Relationship Between Neuroendocrine and Immune Gene Expression in Small Cell Lung Cancer

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

Screening of Botanical Drugs Against Lassa Virus Entry

This study screens a botanical drug library to identify inhibitors of Lassa virus entry, finding two compounds with distinct mechanisms of action.

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damage and constitutes an antiviral target

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug Carmofur

This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.