Author

F. Perocchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Wettmarshausen· 3 shared A. A. Pittis· 2 shared A. Leimpek· 2 shared T. Gabaldon· 2 shared V. Goh· 2 shared Y. Cheng· 2 shared A. Cebrian-Serrano· 1 shared A. Konnerth· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

J. Wettmarshausen

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Author profile →

5 papers

Recent·Most cited

Systematic mapping of MCU-mediated mitochondrial calcium signaling networks

H. C. Delgado de la Herran, D. V. Reane, Y. Cheng, M. Katona, F. Hosp, E. Greotti, J. Wettmarshausen, M. Patron, H. Mohr, N. Prudente de Mello, M. Chudenkova, M. Gorza, S. Walia, M. S.-F. Feng, A. Leimpek, , F. Perocchi

This study maps the MCU-mediated mitochondrial calcium signaling network using proteomics, identifying 89 new interactors and their roles in disease-related pathways.

bioRxiv · Feb 20, 2024 · PreprintCell Biology

Adaptive mitochondrial regulation of the proteasome

T. Meul, K. Berschneider, S. Schmitt, C. H. Mayr, L. F. Mattner, H. B. Schiller, A. Yazgili, X. Wang, C. Lukas, C. Prehn, J. Adamski, E. Graf, T. Schwarzmayr, F. Perocchi, A. Kukat, , S. Meiners

This study shows mitochondrial dysfunction reduces 26S proteasome assembly and activity, which can be reversed by aspartate or pyruvate supplementation.

bioRxiv · Apr 7, 2020 · PreprintCell Biology

Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calciumuniporter

A. A. Pittis, V. Goh, A. Cebrian-Serrano, J. Wettmarhausen, F. Perocchi, T. Gabaldon

The paper identifies EMRE in fungi, resolving the evolutionary paradox of MCU homologs in fungi lacking other uniporter components by showing EMRE and 'animal-like' MICU1 and MCU form a functional complex in chytrid fungi.

bioRxiv · Mar 24, 2020Evolutionary Biology

Profound functional and molecular diversity of mitochondria revealed by cell type-specific profiling in vivo

C. Fecher, L. Trovo, S. A. Müller, N. Snaidero, J. Wettmarshausen, S. Heink, O. Ortiz, I. Wagner, R. Kühn, J. Hartmann, R. M. Karl, A. Konnerth, T. Korn, W. Wurst, D. Merkler, , T. Misgeld

The paper profiles mitochondrial proteomes in specific neural cell types to reveal functional and molecular diversity across cell types in mice and humans.

bioRxiv · Aug 29, 2018Cell Biology

MICU1 modulates MCU ion selectivity and tolerance to manganese stress

J. Wettmarshausen, V. Goh, U. Tripathi, A. Leimpek, Y. Cheng, A. A. Pittis, T. Gabaldon, D. Mokranjac, F. Perocchi

This study shows MICU1 is essential for MCU ion selectivity and protects cells from manganese toxicity.

bioRxiv · Jul 18, 2018 · PreprintCell Biology