T. Gabaldon

Genome-wide RNA structural determination in Candida yeast pathogens

This study investigates RNA structure in Candida pathogens using genome-wide probing, revealing structural conservation, SNP impacts, and conserved hairpin features in lncRNAs.

A yeast love triangle: multiple hybridizations shape genome evolution in the Pichia cactophila species complex.

The paper sequenced and compared genomes of yeast species in the Pichia cactophila complex to show recurrent hybridizations and propose new species classifications.

Stability of Oral and Fecal Microbiome at Room Temperature: Impact on Diversity

The paper assesses the stability of oral and fecal microbiome samples stored at room temperature for 15 days using different preservation methods, finding minimal changes in alpha diversity and relative abundances.

A multidimensional assessment of in-host fitness costs of drug resistance in the opportunistic fungal pathogen Candida glabrata

This study assesses the fitness costs of drug resistance in C. glabrata isolates across different host environments, showing reduced fitness in macrophages and gut but comparable fitness in the spleen.

Overlooked Candida glabrata petites are echinocandin tolerant, induce host inflammatory responses, and display poor in vivo fitness

This study investigates petite C. glabrata strains, showing they are echinocandin tolerant, induce inflammation, and have poor in vivo fitness, with low global prevalence.

Positive selection in gamete interaction proteins in Carnivora

The paper analyzes molecular evolution of gamete interaction proteins in Carnivora, finding positive selection in ZP proteins and IZUMO1 but not JUNO.

The little skate genome and the evolutionary emergence of wing-like fin appendages

This study identifies genomic rearrangements and regulatory changes in the little skate that contribute to the evolution of wing-like fin appendages.

Multiple hybridization events punctuate the evolutionary trajectory of Malassezia furfur

This study identifies multiple hybridization events in Malassezia furfur through comparative genomics and reveals a pseudobipolar mating system.

Transient mitochondria dysfunction confers fungal cross-resistance between macrophages and fluconazole

This study shows that C. glabrata's mitochondrial dysfunction confers cross-resistance to antifungals and macrophages, suggesting a bet-hedging strategy.

Impact of sleep fragmentation, heart failure, and their combination, on the gut microbiome

This study examines how heart failure, sleep fragmentation, and their combination affect the gut microbiome in mice, finding no synergistic effects and some antagonistic interactions.

Timing the origin of eukaryotic cellular complexity with ancient duplications

The paper uses phylogenomics to infer the timing of gene duplications during eukaryogenesis, showing early expansion of cytoskeletal and membrane trafficking genes and later expansion after mitochondrial endosymbiosis.

Functional characterization of SARS-CoV-2 infection suggests a complex inflammatory response and metabolic alterations

This study analyzes RNAseq data from COVID-19 patients and healthy controls to identify inflammatory and metabolic changes associated with SARS-CoV-2 infection.

Genomic evidence for recurrent genetic admixture during domestication mediterranean olive trees (Olea europaea).

This study analyzes genomic data from olive trees to show genetic admixture during domestication and identifies selected genes related to stress response and development.

Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calciumuniporter

The paper identifies EMRE in fungi, resolving the evolutionary paradox of MCU homologs in fungi lacking other uniporter components by showing EMRE and 'animal-like' MICU1 and MCU form a functional complex in chytrid fungi.

Functional characterization of clinical isolates of the opportunistic fungal pathogen Aspergillus nidulans

This study characterizes two clinical isolates of A. nidulans, showing differences in growth, metabolism, stress response, and virulence compared to a reference strain.

Genomic evidence for a hybrid origin of the yeast opportunistic pathogen Candida albicans

The paper provides genomic evidence that Candida albicans originated from a hybrid ancestor, showing patterns of heterozygosity inconsistent with vertical evolution.

A blueprint of seed desiccation sensitivity in the genome of Castanospermum australe

This study sequenced the genome of Castanospermum australe, a desiccation-sensitive legume, and found that its seeds remain metabolically active and lack mechanisms for desiccation tolerance.

Skin microbiome modulation induced by probiotic solutions

The paper demonstrates that applying donor microbiome mixtures can alter recipient skin microbiome composition, with engraftment levels depending on donor-recipient compatibility and bacterial load.

Transcriptomic analyses reveal groups of co-expressed, syntenic lncRNAs in four species of the genus Caenorhabditis

The paper annotates lncRNAs in four Caenorhabditis species using transcriptomic data and identifies conserved synteny and expression patterns.

Phylogenomics of the olive tree (Olea europaea) disentangles ancient allo- and autopolyploidizations in Lamiales.

The paper uses phylogenomics to identify and distinguish between ancient allo- and autopolyploidization events in the olive tree lineage.

Distinct roles of the polarity factors Boi1 and Boi2 in the control of exocytosis and abscission in budding yeast

This study identifies distinct roles of Boi1 and Boi2 in budding yeast, showing Boi1/2's role in exocytosis and Boi2's role in abscission inhibition during cytokinesis.