Host Gastric Corpus Microenvironment Facilitates Ascaris Suum Larval Hatching And Infection in a Murine Model
Y. WU, G. ADENIYI-IPADEOLA, M. ADKINS-THREATS, M. SEASOCK, C. SUAREZ-REYES, F. RICARDO, M. E. BOTTAZZI, L. SONG, J. C. MILLS, J. E. Weatherhead
This study shows that Ascaris suum larvae hatch in the host stomach, not the small intestine, using gastric acid and AMCase, and demonstrates that inhibiting these factors reduces parasitic burden and lung disease.
bioRxiv · Jun 9, 2023 · PreprintMicrobiology