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10 papers
Recent·Most cited
K. Jones, D. M. Nguyen, C. Poveda, J. Pollet, F. Gusovsky, M. E. Bottazzi, P. J. Hotez
This study evaluates the impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection, finding that the treatment better preserves liver health compared to curative doses of benznidazole.
bioRxiv · Jul 11, 2023Pathology
Y. WU, G. ADENIYI-IPADEOLA, M. ADKINS-THREATS, M. SEASOCK, C. SUAREZ-REYES, F. RICARDO, M. E. BOTTAZZI, L. SONG, J. C. MILLS, J. E. Weatherhead
This study shows that Ascaris suum larvae hatch in the host stomach, not the small intestine, using gastric acid and AMCase, and demonstrates that inhibiting these factors reduces parasitic burden and lung disease.
bioRxiv · Jun 9, 2023 · PreprintMicrobiology
V. M. Dzul-Huchim, M. J. Ramirez-Sierra, P. P. Martinez-Vega, M. E. Rosado-Vallado, V. E. Arana-Argaez, J. Ortega-Lopez, F. Gusovsky, E. Dumonteil, J. V. Cruz-Chan, P. Hotez, M. E. Bottazzi, L. E. Villanueva Lizama
This study shows that combining low-dose benznidazole with a bivalent recombinant protein vaccine reduces cardiac fibrosis in mice infected with Trypanosoma cruzi.
bioRxiv · Feb 16, 2022Immunology
E. Nanishi, F. Borriello, T. R. O'Meara, M. E. McGrath, Y. Saito, R. E. Haupt, H.-S. Seo, S. D. van Haren, B. Brook, J. Chen, J. Diray-Arce, S. Doss-Gollin, M. De Leon, K. Chew, M. Menon, , D. J. Dowling
This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.
bioRxiv · May 20, 2021Immunology
J. Lee, Z. Liu, W.-H. Chen, J. Wei, R. Kundu, R. Adhikari, J. Altieri Rivera, P. M. Gillespie, U. Strych, B. Zhan, P. J. Hotez, M. E. Bottazzi
The paper optimizes the production process for a SARS-CoV-2 vaccine candidate, achieving high yield and purity through yeast fermentation and chromatographic purification.
bioRxiv · Dec 30, 2020Immunology
W.-H. Chen, J. Wei, R. T. Kundu, R. Adhikari, Z. Liu, J. Lee, L. Versteeg, C. Poveda, B. Keegan, M. J. Villar, A. C. de Araujo Leao, J. Altieri Rivera, P. M. Gillespie, J. Pollet, U. Strych, , M. E. Bottazzi
The paper genetically modifies SARS-CoV-2 RBD variants in yeast to identify a more stable and manufacturable vaccine candidate.
bioRxiv · Nov 9, 2020Immunology
J. Pollet, W.-H. Chen, L. Versteeg, B. Keegan, B. Zhan, J. Wei, Z. Liu, J. Lee, R. Kundu, R. Adhikari, C. Poveda, M. J. Villar Mondragon, A. C. de Araujo Leao, J. Altieri Rivera, Z. Momin, , M. E. Bottazzi
This study develops a yeast-expressed SARS-CoV-2 RBD protein vaccine candidate, RBD219-N1C1, which induces neutralizing antibodies and T-cell responses in mice.
bioRxiv · Nov 4, 2020Immunology
K. A. Hoffman, P. J. Hotez, M. E. Bottazzi, E. Hossain, Z. Liu, K. M. Jones, L.-I. McCall
This study examines metabolomic changes in the heart during chronic T. cruzi infection, linking metabolic alterations to cardiac fibrosis and inflammation.
bioRxiv · Sep 17, 2020Microbiology
G. G. Mekonnen, B. A. Tedla, D. Pickering, L. Becker, L. Wang, B. Zhan, M. E. Bottazzi, A. Loukas, J. Sotillo, M. S. Pearson
The paper identifies extracellular vesicle proteins from Schistosoma haematobium and shows that vaccinating mice with recombinant tetraspanins reduces egg burdens in a heterologous schistosomiasis model.
Vaccines · Jul 24, 2020Peer-reviewedMicrobiology
W.-H. Chen, X. Tao, A. Agrawal, A. Algaissi, B.-H. Peng, J. Pollet, U. Strych, M. E. Bottazzi, P. J. Hotez, S. Lustigman, L. Du, S. Jiang, C.-T. K. Tseng
This paper develops a SARS-CoV subunit vaccine using yeast-expressed RBD219-N1 with Alhydrogel® and shows it provides full protection against SARS-CoV challenge in mice.
bioRxiv · May 15, 2020Immunology