Cell BiologyBone ResearchPeer-reviewed
The ZNF687 mutation of Paget's disease associated with giant cell tumour causes severe bone remodelling alteration as a result of a deregulated osteoclast transcriptional program
S. Russo, F. Scotto di Carlo, G. Fortunato…·F. Gianfrancesco
This study identifies a ZNF687 mutation causing Paget's disease by disrupting osteoclast function and bone remodeling in mice.
DOI 10.1038/s41413-023-00250-3