F. Gianfrancesco

The ZNF687 mutation of Paget's disease associated with giant cell tumour causes severe bone remodelling alteration as a result of a deregulated osteoclast transcriptional program

This study identifies a ZNF687 mutation causing Paget's disease by disrupting osteoclast function and bone remodeling in mice.

Profilin 1 deficiency drives mitotic defects and impairs genome stability

This study shows that Profilin 1 deficiency causes mitotic defects and genome instability in cancer cells.