Identification of anti-severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) oxysterol derivatives in vitro
H. Ohashi, F. Wang, F. Stappenbeck, K. Tsuchimoto, C. Kobayashi, W. Saso, M. Kataoka, K. Kuramochi, M. Muramatsu, T. Suzuki, C. Sureau, M. Takeda, T. Wakita, F. Parhami, K. Watashi
This study identifies oxysterol derivatives with anti-SARS-CoV-2 activity, showing that Oxy210 and Oxy232 inhibit viral replication by disrupting double membrane vesicles.
bioRxiv · Jan 31, 2021Microbiology