Targeted Transcriptional Repression by Induced Proximity
Christian E. Stieger, Xinru Chen, Christina C. Kuismi, Dustin Dovala, Daniel Fuller, Andreas O. Frank, Mikias Woldegiorgis, Megan Bruce-Smythe, Fabian Wu, Nicolas Pizzato, Jeffrey M. McKenna, Cory M. Johannessen, Barna D. Fodor, Markus Schirle, Daniel K. Nomura
This paper introduces TRACERs, small-molecule drugs that silence transcription factors in cancer by recruiting repressor complexes, showing efficacy against ER and AR in breast and prostate cancer.
ACS Central Science · Jun 11, 2026Peer-reviewedBiochemistry