Sebastian Steinhauser

The paper identifies ZNF469 as a transcription factor regulating collagen production in liver fibrosis through computational analysis and experimental validation.

This study benchmarks nine TF prioritization tools using H3K27ac ChIP-seq data from 84 perturbation experiments, identifying three top-performing tools.

The paper introduces SPACE and SPACEmap to identify chromatin-associated RBPs and their interactions, revealing that many bind chromatin via intrinsically disordered regions.

ChromWave predicts TF and nucleosome occupancy competition using deep learning, showing accurate predictions in yeast and human promoters.

The paper identifies LIN28A as a key factor in mRNA decay during epiblast morphogenesis, linking cell identity changes to embryonic growth through nucleo-cytoplasmic translocation.

The paper challenges the established model of neural induction by showing that cells commit to anterior or posterior regional identities before acquiring neural identity.

The paper introduces a method to disentangle multi-omics data and identifies regulatory mechanisms in human blood cells.