Author

Fan Fan

Janssen Research & Development (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Organism:multiple species· 1

Frequent Co-Authors

CLIFFORD C. STEPHANiD· 1 shared Lee M. EllisiD· 1 shared Rajat BhattacharyaiD· 1 shared Reid Trenton PowelliD· 1 shared Scott KopetziD· 1 shared Shreyas U. HirwayiD· 1 shared Susmita GhoshiD· 1 shared Xiao XuiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCancer Biology

CLIFFORD C. STEPHANORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Large-Scale Concordance Study of Toxicity Findings Across Preclinical Species and Humans for Small Molecules and Biologics in Drug Development

Xin Liu, Fan Fan

This study identifies concordant toxicity findings across preclinical species and humans for drugs, using a large dataset and novel methods to improve translational safety science.

bioRxiv · Jan 30, 2026 · PreprintBioinformatics

A Novel Computational Machine Learning Pipeline to Quantify Similarities in Three-Dimensional Protein Structures

Shreyas U. Hirway, Xiao Xu, Fan Fan

The paper develops a machine learning pipeline to quantify 3D protein structure similarity across species to improve animal model selection for drug development.

Toxicological Sciences · Jan 17, 2025Peer-reviewedPharmacology & Toxicology

Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer

Susmita Ghosh, Fan Fan, Reid Trenton Powell, Yong Sung Park, CLIFFORD C. STEPHAN, Scott Kopetz, Lee M. Ellis, Rajat Bhattacharya

This study identifies paclitaxel as a synergistic partner for trametinib in KRAS-mutated colorectal cancer, showing enhanced anti-tumor effects in vitro and in vivo.

Therapeutic Advances in Medical Oncology · Jan 1, 2024Peer-reviewedCancer Biology