Author

Zhiyu Cai

Sir Run Run Shaw HospitalORCID 0009-0004-3239-5358Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Wei MoiD· 4 shared Bo-Xin Zhang· 3 shared Qiang CheniD· 3 shared Zhang-Hua Yang· 3 shared Baizhou LiiD· 2 shared Huan-Feng Ye· 2 shared Jia Huang· 2 shared Lei Wu· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Wei MoORCID

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4 papers

Recent·Most cited

Z-RNA-ZBP1 axis drives Tau-mediated neurodegeneration

Wei Liu, Song-Ang Wu, Bo-Xin Zhang, Shaoyu Guo, Lang Li, Wenjing Sun, Xushen Xiong, Jiuhong Nan, Jianfeng Wu, Linghui Zeng, Pilong Li, Zhiyu Cai, Huan-Feng Ye, Shuo Zhang, Sheng Nie, , Wei Mo

The paper identifies the Z-RNA-ZBP1 axis as a driver of Tau-mediated neurodegeneration and shows that ZBP1 inhibition can alleviate cognitive deficits in Tau-transgenic mice.

bioRxiv · Feb 17, 2026 · PreprintNeuroscience

Oxidation-Driven mtDNA B-Z Transition Activates ZBP1 to Mediate Acetaminophen Hepatotoxicity

Zhang-Hua Yang, Bo-Xin Zhang, Huan-Feng Ye, Liang Shi, Rui Gong, Zhiyu Cai, Qiang Chen, Lei Wu, Jia Huang, Le Zhang, Huipeng Jiao, Pinglong Xu, Qinjie Weng, Jie Zhang, Jinheng Pan, , Wei Mo

This study identifies oxidative mtDNA B-Z transitions activating ZBP1 as a key mechanism in APAP-induced liver failure and shows TH107854 can reverse this process.

Vita · Jan 1, 2026Peer-reviewedCell Biology

ZBP1 Senses Splicing Aberration through Z-RNA to promote Cell Death

Zhang-Hua Yang, Puqi Wu, Bo-Xin Zhang, Congrong Yang, Jia Huang, Lei Wu, Shaoyu Guo, Yuenan Zhou, Yuanhui Mao, Yafei Yin, Xiurong Wu, Pu Cheng, Baizhou Li, Rongbin Zhou, Han‐Ming Shen, , Wei Mo

This study shows that spliceosome inhibition generates Z-RNA, sensed by ZBP1 to trigger necroptosis in response to splicing aberrations.

Molecular Cell · Apr 22, 2025Peer-reviewedCell Biology

Microglial Piezo1 senses Aβ fibrils stiffness to restrict Alzheimer's disease

Jin Hu, Qiang Chen, Hongrui Zhu, Lichao Hou, Wei Liu, Qihua Yang, Huidan Shen, Guolin Chai, Boxin Zhang, Shaoxuan Chen, Zhiyu Cai, Chongxin Wu, Fan Hong, Hongda Li, Sifang Chen, , Wei Mo

This study shows that microglial Piezo1 senses Aβ fibril stiffness, influencing AD pathology by affecting phagocytosis and plaque compaction.

Neuron · Nov 10, 2022Peer-reviewedNeuroscience