Author

Fan Wu

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Animal Behavior & Cognition· 1 Bioinformatics· 1 Cancer Biology· 1 Cell Biology· 1 Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Denis WirtziD· 2 shared Alejandro PenaiD· 1 shared André ForjaziD· 1 shared Arrun SivasubramanianiD· 1 shared Ashley L. KiemeniD· 1 shared Benjamin WeniD· 1 shared Bofei YuiD· 1 shared Brian A. PedroiD· 1 shared

Activity by Year

2025-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Denis WirtzORCID

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Author profile →

6 papers

Recent·Most cited

Gut microbiota-derived indole-3-propionic acid preserves dorsal hippocampal catecholamines to prevent post-stroke cognitive impairment

Yisi Liu, Huaying Zhang, Fangbo Xia, Xuxuan Gao, Fan Wu, Xin Zhao, Mengxi Li, Yanni Zheng, Siqi Yan, Kaiyu Xu, Muxuan Chen, Yueran Ren, Weike Hu, Zhuang Li, Jia Yin, , Dongxin Zhang

This study identifies indole-3-propionic acid (IPA) as a gut microbiota-derived metabolite that prevents post-stroke cognitive impairment by preserving catecholamines in the dorsal hippocampus.

mSystems · Oct 7, 2026Peer-reviewedNeuroscience

Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction

Kanako Iwasaki, Hui Pan, Jonathan M. Dreyfuss, Maya Jackson, Sergii Domanskyi, Dylan Baker, Priscila Carapeto, Christopher Cahill, Sandra Le, Francesko Hela, Juliana Alcoforado Diniz, Giray Naim Eryilmaz, Fan Wu, Pei-Hsun Wu, Bofei Yu, , Cristina Aguayo‐Mazzucato

The paper identifies two distinct senescent β-cell subpopulations with different functional roles in islet aging and dysfunction using single-cell proteomics and transcriptomics.

bioRxiv · May 28, 2026 · PreprintCell Biology

Integrative Single-Cell and Multi-Cohort Analysis of the Netrin-1 Signaling Pathway Reveals Divergent Prognostic Trends and Sex-Dimorphic Associations in Glioblastoma

Yang Bai, Huan Xia, Fan Wu, Xiang Tan, Xinmin Wu

This study analyzes Netrin-1 pathway gene expression in glioblastoma using single-cell and bulk RNA-seq data, identifying NTN1 as a risk factor and sex-dimorphic associations.

bioRxiv · May 20, 2026 · PreprintCancer Biology

Virtual multiplex staining of the pancreatic islets across type 1 diabetes progression using a Schroedinger bridge

Ye Shen, Won June Cho, Saurabh Joshi, Benjamin Wen, Swarnagouri Naganathanhalli, Maria L. Beery, Casey Grubel, Arrun Sivasubramanian, André Forjaz, Mia P. Grahn, Lucie Dequiedt, Yuru Huang, Fan Wu, Brian A. Pedro, Laura DeLong Wood, , Ashley L. Kiemen

This paper introduces SMILE, a diffusion model for converting H&E stains to multiplex IHC images, showing superior performance in pancreatic islet analysis and breast cancer stain conversion.

bioRxiv · Apr 17, 2026 · PreprintBioinformatics

Sex-determination cascade orchestrates male-male pheromone synthesis in the bean bug

Ji‐Chong Zhuo, Hai‐Qiang Wang, Qing-Ling Hu, Ze-Ping Mao, Lin Wang, Fan Wu, Jia-Bao Lu, Hai‐Jian Huang, Zong-tao Sun, Fei Yan, Jianping Chen, Jun-Min Li, Chuan-Xi Zhang

The paper identifies two male-male pheromones in bean bugs and shows their synthesis is controlled by the sex-determination cascade Rpfmd-Rpdsx.

bioRxiv · Mar 11, 2026 · PreprintAnimal Behavior & Cognition

Structure and function of the nairovirus cap-snatching endonuclease

Wenhua Kuang, Zhenhua Tian, Gan Zhang, Fan Wu, J. M. Li, Jingjing Tang, Huanyu Zhang, Xinyue Zhuo, Zhìhóng Hú, Mengdi Wang, Haiyan Zhao, Zengqin Deng

This study characterizes the structure and function of nairovirus cap-snatching endonucleases, revealing a unique two-metal-ion mechanism and identifying potent inhibitors.

Nucleic Acids Research · Dec 24, 2025Peer-reviewedMicrobiology