Juliana Alcoforado Diniz

DIANNE enables rapid training and inference of spatial differential attributes in histology images without manual annotations, using mixup augmentation and foundation models.

The paper identifies two distinct senescent β-cell subpopulations with different functional roles in islet aging and dysfunction using single-cell proteomics and transcriptomics.

The paper identifies senescent β-cell subpopulations in humans and mice that induce pathologic dysfunction through paracrine signaling and shows JAK inhibitors can reverse this effect.

This study functionally characterizes PRMTs in Leishmania braziliensis, showing PRMT1 and PRMT5 are required for macrophage infection and axenic amastigote proliferation.