Jonathan M. Dreyfuss

ScreenDMT identifies metabolites consistently linked to sleep disorders across three human cohorts, revealing replicable associations with insomnia, sleep duration, and daytime sleepiness.

The paper identifies two distinct senescent β-cell subpopulations with different functional roles in islet aging and dysfunction using single-cell proteomics and transcriptomics.

The paper identifies pregnancy-associated miRNAs that regulate HIV-interacting genes using longitudinal serum samples from Ugandan and Zimbabwean participants.

This study identifies miRNA dysregulation in vaginal dysbiosis linked to HIV risk by targeting the HIV-host interactome.

This study identifies differentially expressed miRNAs regulating drug metabolizing enzymes and transporters during pregnancy and lactation, revealing their association with sex hormone levels and placental function.

The paper identifies linoleic acid diols that inversely associate with BMI and activate adipocyte calcium fluxes using a novel tool called ScreenDMT.

This study shows that fructose metabolism via KHK-C increases ER stress and modulates the hepatic transcriptome, contributing to NAFLD progression in both genetic and diet-induced models.

The paper identifies mediators of improved glycemia after gastric bypass surgery using a high-throughput mediation analysis method applied to plasma proteome and metabolome data.