This study characterizes the structure and function of nairovirus cap-snatching endonucleases, revealing a unique two-metal-ion mechanism and identifying potent inhibitors.

Nucleic Acids Research · Dec 24, 2025Peer-reviewedMicrobiology

Neutralizing antibodies elicited by Nipah virus G-head nanoparticle target diverse sites and inhibit receptor binding and fusion

Dan Zhou, Yong Wang, Yanfeng Yao, Wenhua Kuang, Rao Cheng, Gan Zhang, Hang Liu, Xin Li, Sandra Chiu, Zengqin Deng, Haiyan Zhao

This study characterizes monoclonal antibodies against Nipah virus G-head nanoparticle, identifying neutralizing mechanisms and epitopes that could inform vaccine and therapeutic development.

bioRxiv · Feb 16, 2025 · PreprintImmunology

Coupling of Ca2+ and voltage activation in BK channels through the αB helix/voltage sensor interface

Yanyan Geng, Zengqin Deng, Guohui Zhang, Gonzalo Budelli, Alice Butler, Peng Yuan, Jianmin Cui, Lawrence Salkoff, Karl L. Magleby

This study investigates how the B helix/voltage sensor interface in BK channels couples Ca2+ and voltage activation, showing its role in transducing both signals to pore opening.

Proceedings of the National Academy of Sciences · Jun 8, 2020Peer-reviewedNeuroscience