Centrosome depletion rewires mitosis to impose dependence on the AURK-TPX2 axis
Zhong Y. Yeow, Fang-Chi Chang, Lance Y. Xu, Andrew Jon Holland
The paper identifies genetic suppressors of centrosome depletion sensitivity, revealing the AURKA-TPX2 axis as a critical pathway for spindle assembly under centrosome depletion.
bioRxiv · May 6, 2026 · PreprintCancer Biology