Andrew Jon Holland

The paper identifies genetic suppressors of centrosome depletion sensitivity, revealing the AURKA-TPX2 axis as a critical pathway for spindle assembly under centrosome depletion.

This study shows DNA damage response pathways are essential for multiciliated cell differentiation by enabling centriole amplification through a pseudo-cell cycle mechanism.

The paper introduces an optimized AID system for reversible and sustained protein degradation in live mice, demonstrating its effectiveness in degrading CEP192 and causing cell division failure.

The paper reports cryo-EM structures of Haspin kinase bound to a nucleosome, revealing its unique DNA supergroove binding mechanism for phosphorylating H3T3.

This study shows that HYLS1 mutations cause centriole structural defects leading to ciliary dysfunction and developmental issues in mice, mirroring human Hydrolethalus Syndrome.

The paper shows that precise centriole counts are essential for B cell development but not for immune function.

This paper elucidates how TRIM37 regulates mesoscale MTOCs through a multi-step activation mechanism involving substrate recognition, oligomerization, and dimerization.

This study shows the MCC cell cycle variant accelerates centriole biogenesis by overlapping two cycles to produce multiple mature centrioles without cell division.

The paper develops a method using inducible protein degradation and phosphoproteomics to identify kinase-substrate relationships, showing high selectivity and correlation with chemical inhibition.