Histone 3 lysine 9 dimethylation by the G9a-GLP heterodimer requires intranucleosomal product reading
Farzad Yousefi, Eric Simental, Yongming Du, Samuel D. Whedon, Michael J. Trnka, Daniel Darling, Sohpia Jia, Barbara Panning, Philip A Cole, Mario Halić, Bassem Al‐Sady
This paper investigates the G9a-GLP heterodimer's feedback mechanism, showing that both ANK domains are required for H3K9 dimethylation and nucleosome binding, suggesting intranucleosomal feedback.
bioRxiv · Feb 5, 2026 · PreprintBiochemistry