Barbara Panning

Histone 3 lysine 9 dimethylation by the G9a-GLP heterodimer requires intranucleosomal product reading

This paper investigates the G9a-GLP heterodimer's feedback mechanism, showing that both ANK domains are required for H3K9 dimethylation and nucleosome binding, suggesting intranucleosomal feedback.

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate

The paper shows that the nuclear periphery represses H3K9me2-marked genes and transposons, and its loss disrupts cell fate transitions in mESCs.

O-GlcNAc modifications regulate lamin A tail processing

This study investigates how O-GlcNAc modifications influence lamin A tail processing and identifies a potential link between glucose metabolism and lamina biogenesis.

The maternal X chromosome impairs cognition and accelerates brain aging through epigenetic modulation in female mice

X chromosome factor Kdm6a enhances memory independent of its demethylase function in the aging XY male brain

The paper shows that increasing Kdm6a in aging male mice improves memory without needing its demethylase function.

A dose-sensitive OGT-TET3 complex is necessary for normal Xist RNA distribution and function

The paper identifies an OGT-TET3 complex that regulates 5mC and 5hmC levels and XCI in female mouse embryonic stem cells.

Deep profiling reveals substantial heterogeneity of integration outcomes in CRISPR knock-in experiments

Long-read sequencing with the knock-knock pipeline profiles CRISPR knock-in repair, finding perfect homology-directed repair is often a minority of integration events and mis-integration varies by context.