Bassem Al‐Sady

This paper investigates the G9a-GLP heterodimer's feedback mechanism, showing that both ANK domains are required for H3K9 dimethylation and nucleosome binding, suggesting intranucleosomal feedback.

This study shows that phosphorylation of HP1/Swi6 reduces competition with Suv39/Clr4 by altering its nucleosome affinity and oligomerization, promoting H3K9me3 spreading in S. pombe.

The paper identifies distinct epigenetic subdomains in subtelomeric heterochromatin of S. pombe, showing position-specific silencing and the role of structural variants in epigenetic stability.

The paper shows that the nuclear periphery represses H3K9me2-marked genes and transposons, and its loss disrupts cell fate transitions in mESCs.

This study identifies domain-specific heterochromatin regulators in Schizosaccharomyces pombe using quantitative methods and genetic screening, revealing Dhm2's role in heterochromatin maintenance and replication fidelity.

This study identifies the dual role of the fission yeast Ccr4-Not complex in gene silencing and heterochromatin spreading through RNA deadenylation and protein ubiquitinylation.

The paper identifies gene regulators that influence heterochromatin spreading in different chromatin contexts using a fission yeast deletion library and sensor system.

This study identifies FACT as a histone chaperone that promotes heterochromatin spreading by regulating histone turnover and H3K9 methylation states.

The paper identifies a mechanism by which Set1/COMPASS prevents heterochromatin invasion at euchromatic sites through inhibition of Suv39/Clr4 and disruption of nucleosome stability.

The paper shows that RNAi-induced heterochromatin spread is stochastic, while a memory element called REIII provides deterministic, high-fidelity spreading in fission yeast.