Author

Eric Simental

University of California, San FranciscoORCID 0000-0002-8638-6578Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Bassem Al‐SadyiD· 3 shared Barbara PanningiD· 2 shared Eric W. MartiniD· 2 shared Abigail L. BuchwalteriD· 1 shared Ahmed A. A. AmineiD· 1 shared Catherine TaniD· 1 shared Charlie Allen· 1 shared Dana R Kennedy· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

Bassem Al‐SadyORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Histone 3 lysine 9 dimethylation by the G9a-GLP heterodimer requires intranucleosomal product reading

Farzad Yousefi, Eric Simental, Yongming Du, Samuel D. Whedon, Michael J. Trnka, Daniel Darling, Sohpia Jia, Barbara Panning, Philip A Cole, Mario Halić, Bassem Al‐Sady

This paper investigates the G9a-GLP heterodimer's feedback mechanism, showing that both ANK domains are required for H3K9 dimethylation and nucleosome binding, suggesting intranucleosomal feedback.

bioRxiv · Feb 5, 2026 · PreprintBiochemistry

Phosphorylation of HP1/Swi6 relieves competition with Suv39/Clr4 on nucleosomes and enables H3K9 trimethyl spreading.

Dana R Kennedy, Joël P.C. Lemiere, Ahmed A. A. Amine, Eric W. Martin, Catherine Tan, Eric Simental, Julian R. Braxton, Robert A. Maxwell, Bassem Al‐Sady

This study shows that phosphorylation of HP1/Swi6 reduces competition with Suv39/Clr4 by altering its nucleosome affinity and oligomerization, promoting H3K9me3 spreading in S. pombe.

Nucleic Acids Research · Oct 22, 2025Peer-reviewedMolecular Biology

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate

Harold C. Marin, Charlie Allen, Eric Simental, Eric W. Martin, Barbara Panning, Bassem Al‐Sady, Abigail L. Buchwalter

The paper shows that the nuclear periphery represses H3K9me2-marked genes and transposons, and its loss disrupts cell fate transitions in mESCs.

Nature Cell Biology · Jul 22, 2025Peer-reviewedCell Biology