PBRM1 directs PBAF to pericentromeres and protects centromere integrity
Karen A. Lane, Alison Harrod, Lillian Wu, Theodoros I. Roumeliotis, Hugang Feng, Shane Foo, Katheryn Begg, Federica Schiavoni, Noa Amin, Frank T. Zenke, Alan A. Melcher, Jyoti Sharma Choudhary, Jessica A. Downs
This study identifies PBAF as a protector of centromere and pericentromere structure, showing that PBRM1 loss leads to centromere fragility and therapeutic vulnerability.
Nature Communications · Feb 26, 2025Peer-reviewedMolecular Biology