Jessica A. Downs

This study identifies a non-centromeric role for CENP-B in binding hairpin motifs in chromosome arms, leading to dysregulated gene expression upon depletion.

This study uses PRISMA to identify and map novel ARID1A interactions at high sequence resolution, revealing new interactors and a regulatory mechanism involving CDK2 phosphorylation.

This study shows ARID1A deficiency increases sensitivity to the G4 ligand pyridostatin due to impaired DNA repair, highlighting a role for ARID1A in G4 ligand-induced DNA damage responses.

The paper introduces CRISPR-Taiji to engineer chromosome-specific aneuploidy and characterizes its transcriptomic effects, linking aneuploidy to ccRCC phenotypes.

This study identifies PBAF as a protector of centromere and pericentromere structure, showing that PBRM1 loss leads to centromere fragility and therapeutic vulnerability.

The paper identifies the CIP2A-TOPBP1 axis as a regulator of mitotic DNA repair pathways, showing it promotes MiDAS and MMEJ through distinct mechanisms.