Local glucocorticoid signalling promotes pancreatic cancer
Clara Veiga-Villauriz, Hosni A. M. Hussein, Christopher J. Ward, Sanu K. Saji, Soura Chakraborty, Jhuma Pramanik, Yumi Yamashita-Kanemaru, Joanna P. Simpson, Sofia Laforest, Federico Diez, Natalie Z M Homer, Rahul Roychoudhuri, Timotheus Y.F. Halim, Bidesh Mahata
This study identifies Hsd11b1 as a key enzyme promoting glucocorticoid signaling in pancreatic cancer, contributing to immunosuppression and fibrosis, suggesting HSD11B1 as a therapeutic target.
bioRxiv · Nov 14, 2025 · PreprintCancer Biology