Hosni A. M. Hussein

This study identifies Hsd11b1 as a key enzyme promoting glucocorticoid signaling in pancreatic cancer, contributing to immunosuppression and fibrosis, suggesting HSD11B1 as a therapeutic target.

This study shows that immune cell steroidogenesis is essential for resolving inflammation and promoting recovery in acute lung injury.

The paper identifies Posaconazole as a CYP11A1 inhibitor that enhances anti-tumour immunity in a mouse model of lung metastasis.

This study identifies de novo steroidogenesis in mast cells as a novel regulatory mechanism essential for their development, survival, and function, with implications for inflammatory and anaphylactic responses.