MDFIC2 is a sensory neuron-specific PIEZO channel auxiliary subunit
Zijing Zhou, Fei Dai, Delfine Cheng, Xiaonuo Ma, Seyedeh Farzaneh Omidkhoda, J. D. W. Clarke, Huijing Zhang, Michael Laden, Yang Guo, Jinyuan Vero Li, Renjing Liu, Emily S. W. Wong, Yixiao Zhang, Charles David Cox
The paper identifies MDFIC2 as a PIEZO channel auxiliary subunit specifically expressed in mechanosensitive neurons and shows it modulates PIEZO1/2 mechanosensitivity and inactivation kinetics.
Proceedings of the National Academy of Sciences · Apr 9, 2026Peer-reviewedBiophysics