Author

Delfine Cheng

Victor Chang Cardiac Research InstituteORCID 0000-0002-8575-0534Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Delfine Cheng1 paper · Victor Chang Cardiac Research Institute, Sydney, NSW, Australia;

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Charles David CoxiD· 3 shared Yang GuoiD· 2 shared Yixiao ZhangiD· 2 shared Zijing ZhouiD· 2 shared Ben CorryiD· 1 shared Boris MartinaciD· 1 shared Emily S. W. WongiD· 1 shared Evelyn Israel NadariD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiophysics

Charles David CoxORCID

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3 papers

Recent·Most cited

MDFIC2 is a sensory neuron-specific PIEZO channel auxiliary subunit

Zijing Zhou, Fei Dai, Delfine Cheng, Xiaonuo Ma, Seyedeh Farzaneh Omidkhoda, J. D. W. Clarke, Huijing Zhang, Michael Laden, Yang Guo, Jinyuan Vero Li, Renjing Liu, Emily S. W. Wong, Yixiao Zhang, Charles David Cox

The paper identifies MDFIC2 as a PIEZO channel auxiliary subunit specifically expressed in mechanosensitive neurons and shows it modulates PIEZO1/2 mechanosensitivity and inactivation kinetics.

Proceedings of the National Academy of Sciences · Apr 9, 2026Peer-reviewedBiophysics

TMEM63 proteins act as mechanically-activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience

Yiechang Lin, Zijing Zhou, Yaoyao Han, Delfine Cheng, Haoqing Jerry Wang, Lining Arnold Ju, Yixiao Zhang, Charles David Cox, Ben Corry

The paper shows TMEM63 proteins function as mechanically activated lipid scramblases, modulated by cholesterol, contributing to membrane resilience.

Nature Communications · Jan 30, 2026Peer-reviewedBiophysics

Deletion of PIEZO1 in adult cardiomyocytes accelerates cardiac aging and causes premature death

Ze‐Yan Yu, Yang Guo, Scott H. Kesteven, Delfine Cheng, Hanzhou Lei, Jianxin Wu, Evelyn Israel Nadar, Peter Simon Macdonald, Munira Xaymardan, Charles David Cox, Michael Patrick Feneley, Boris Martinac

This study shows that deleting PIEZO1 in adult cardiomyocytes leads to accelerated cardiac aging and premature death in mice.

bioRxiv · Jan 20, 2025 · PreprintBiophysics