A high-resolution dimeric structure reveals a critical role of alpha-helix 9 in apoptotic Bax pore assembly in the mitochondrial membrane
Zhi Zhang, Liujuan Zhou, Chenyi Liao, Fujiao Lv, Fei Qi, Lingyu Du, Justin P. Pogmore, Juan delRosaio, David William Andrews, Bo OuYang, Jialing Lin
This paper presents a high-resolution NMR structure of Bax helix 9, showing its role in dimerization and pore formation during apoptosis, supported by mutagenesis and simulations.
bioRxiv · Dec 30, 2025 · PreprintBiochemistry