David William Andrews

A high-resolution dimeric structure reveals a critical role of alpha-helix 9 in apoptotic Bax pore assembly in the mitochondrial membrane

This paper presents a high-resolution NMR structure of Bax helix 9, showing its role in dimerization and pore formation during apoptosis, supported by mutagenesis and simulations.

Small Molecule Disruption of a Protein Disulfide Isomerase-Containing Multi-Protein Complex Causes Broad Cancer Selective Metabolic Collapse and Tumor Inhibition in vivo

PAV-620 and PAV-805 disrupt PDI-containing complexes, causing metabolic collapse and tumor inhibition in cancer models without toxicity to healthy cells.

BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains

This study identifies a novel interaction between BOK and BCL-2 transmembrane domains that regulates apoptosis and suggests it as a potential drug target.