The Role of the Co-Chaperone DNAJB11 in Polycystic Kidney Disease: Molecular Mechanisms and Cellular Origin of Cyst Formation
Tilman Busch, Björn Neubauer, Lars Schmitt, Isabel Cascante, Luise Knoblich, Oliver Wegehaupt, Felix Schöler, Stefan Tholen, Alexis Hofherr, Christoph Schell, Oliver Schilling, Lukas Westermann, Michael Köttgen
This study investigates DNAJB11's role in atypical ADPKD, showing biallelic loss causes cystic kidney disease and identifying impaired PC1 cleavage as a potential mechanism.
The FASEB Journal · Nov 12, 2024Peer-reviewedMolecular Biology