Stefan Tholen

This study examines how hypomorphic IFT and dynein-2 mutations affect chondrogenic differentiation, ECM composition, and Wnt signaling in ATDC5 organoids, revealing genotype-dependent changes in signaling pathways and ECM.

This study performs time-resolved transcriptomic and ECM proteomic analyses of differentiating ATDC5 cells to characterize chondrogenesis and cartilage ECM formation.

This study shows that dual SHP2/MEK inhibition in pancreatic cancer causes mitochondrial changes and ROS elevation, leading to a therapy-resistant state that can be targeted with GPX4 inhibition.

This paper identifies Rbp3 as an RRM domain protein in Synechocystis that binds mRNAs encoding photosynthesis proteins and localizes near ribosomes.

This study identifies RNA-binding partners and functions of YlxR/RpnM in cyanobacteria, showing its role in RNA maturation, cell division, and nitrogen metabolism.

This study investigates DNAJB11's role in atypical ADPKD, showing biallelic loss causes cystic kidney disease and identifying impaired PC1 cleavage as a potential mechanism.