Oliver Schilling

This study identifies SARS-CoV-2 PLpro's preference for basic amino acids at P1 and secondary motifs involving two basic residues, revealing structural constraints and implications for inhibitor design.

This study examines how hypomorphic IFT and dynein-2 mutations affect chondrogenic differentiation, ECM composition, and Wnt signaling in ATDC5 organoids, revealing genotype-dependent changes in signaling pathways and ECM.

MR-SP2 improves proteome coverage and identification depth for few-cell FFPE samples using an integrated workflow compatible with upward pressure-catapulting LCM.

This study identifies collagen VI as a key ECM component in ccRCC stroma, showing its role in shaping tumor structure, function, and immune response, with implications for TKI therapy.

This study performs time-resolved transcriptomic and ECM proteomic analyses of differentiating ATDC5 cells to characterize chondrogenesis and cartilage ECM formation.

This study shows that dual SHP2/MEK inhibition in pancreatic cancer causes mitochondrial changes and ROS elevation, leading to a therapy-resistant state that can be targeted with GPX4 inhibition.

This study demonstrates the use of iprm-PASEF for in situ, antibody-independent, and multiplexed characterization of amyloid plaques in tissue samples.

This study uses proteomics to characterize sporadic ccRCC, identifying a matrix-dense pseudocapsule and five tumor subtypes with distinct biological features.

This paper identifies Rbp3 as an RRM domain protein in Synechocystis that binds mRNAs encoding photosynthesis proteins and localizes near ribosomes.

This study shows that Chlamydia trachomatis uses membrane vesicles to deliver OmpA to mitochondria, inhibiting apoptosis and promoting bacterial survival in human cells.

This study identifies ANXA4 as a key player in ccRCC, showing its role in membrane repair, transcriptional changes, and tumor microenvironment composition through genetic and computational analyses.

This paper introduces a novel MALDI imaging method combining TIMS-PASEF for multiplexed and spatial peptide identification in tissue samples.

This study investigates DNAJB11's role in atypical ADPKD, showing biallelic loss causes cystic kidney disease and identifying impaired PC1 cleavage as a potential mechanism.

This study identifies proteomic subtypes and recurrence patterns in IDH-wildtype glioblastoma using tissue and serum samples, revealing prognostic markers and proteomic plasticity in recurrent tumors.

This study identifies two proteomic subgroups of intrahepatic cholangiocarcinoma with distinct time-to-recurrence rates and biological processes.

The paper identifies EOMES-induced chromatin accessibility as a key step in initiating mesendoderm lineage commitment during mammalian gastrulation.

The paper performs proteomic analysis of peri-implant crevicular fluid to compare healthy implants, teeth, and peri-implantitis-affected implants, finding distinct proteome alterations in diseased implants.

The paper provides a Galaxy-based pipeline for DIA proteomics analysis, enabling reproducible and accessible processing through a web interface.

The paper integrates mass spectrometry imaging tools into Galaxy to enable accessible, reproducible, and transparent analysis of MSI data.