Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1
Lisa Machner, Alaa Shaikhqasem, Tobias Gruber, Farzad Hamdi, Constanze Breithaupt, Judith Kniest, Felix Wiebe, Marc Lewitzky, C. Parthier, Fotis L. Kyrilis, Jochen Balbach, Panagiotis L. Kastritis, Stephan M. Feller, Milton T. Stubbs
This study identifies how bis-Tyr-phosphorylated Gab1 activates SHP2 by binding both SH2 domains and inducing structural changes.
Structure · Dec 22, 2025Peer-reviewedBiochemistry