Author

Constanze Breithaupt

Martin Luther University Halle-Wittenberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:electronic health records· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alaa ShaikhqasemiD· 2 shared C. ParthieriD· 2 shared Farzad HamdiiD· 2 shared Fotis L. KyrilisiD· 2 shared Lisa Machner· 2 shared Milton T. StubbsiD· 2 shared Panagiotis L. KastritisiD· 2 shared Stephan M. FelleriD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Alaa ShaikhqasemORCID

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2 papers

Recent·Most cited

Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1

Lisa Machner, Alaa Shaikhqasem, Tobias Gruber, Farzad Hamdi, Constanze Breithaupt, Judith Kniest, Felix Wiebe, Marc Lewitzky, C. Parthier, Fotis L. Kyrilis, Jochen Balbach, Panagiotis L. Kastritis, Stephan M. Feller, Milton T. Stubbs

This study identifies how bis-Tyr-phosphorylated Gab1 activates SHP2 by binding both SH2 domains and inducing structural changes.

Structure · Dec 22, 2025Peer-reviewedBiochemistry

Strategies for Mitigating Radiation Damage and Improving Data Completeness in 3D Electron Diffraction of Protein Crystals

Alaa Shaikhqasem, Farzad Hamdi, Lisa Machner, C. Parthier, Constanze Breithaupt, Fotis L. Kyrilis, Stephan M. Feller, Panagiotis L. Kastritis, Milton T. Stubbs

This paper introduces a method to reduce radiation damage and improve data completeness in 3D electron diffraction by using multi-position acquisition from multiple crystals.

Acta Crystallographica Section D Structural Biology · Dec 15, 2025Peer-reviewedBiochemistry