Harnessing Protein Unfolding for Thermosensing: Structural Insights from TRPV3
Andrew Njagi Mugo, Dinesh C. Indurthi, Ryan Chou, Gaya Prasad Yadav, Liguo Wang, Feng Qin
This study reveals a structural mechanism for thermosensing in TRPV3 channels, showing that extreme thermosensitivity arises from protein unfolding and dynamic changes rather than localized sensors.
bioRxiv · Sep 17, 2025 · PreprintPhysiology