Author

Andrew Njagi Mugo

University at Buffalo, State University of New YorkORCID 0000-0001-8783-577XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Ryan Chou· 2 shared Dinesh C. IndurthiiD· 1 shared Feng Qin· 1 shared Feng QiniD· 1 shared Gaya Prasad YadaviD· 1 shared Liguo WangiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersPhysiology

Ryan Chou

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2 papers

Recent·Most cited

Harnessing Protein Unfolding for Thermosensing: Structural Insights from TRPV3

Andrew Njagi Mugo, Dinesh C. Indurthi, Ryan Chou, Gaya Prasad Yadav, Liguo Wang, Feng Qin

This study reveals a structural mechanism for thermosensing in TRPV3 channels, showing that extreme thermosensitivity arises from protein unfolding and dynamic changes rather than localized sensors.

bioRxiv · Sep 17, 2025 · PreprintPhysiology

Protein Dynamics Underlies Strong Temperature Dependence of Heat Receptors

Andrew Njagi Mugo, Ryan Chou, Feng Qin

The paper shows that temperature sensing in TRPV1 channels is linked to protein unfolding and thermal instability, not conventional allosteric mechanisms.

Proceedings of the National Academy of Sciences · Dec 30, 2024Peer-reviewedBiophysics