The TREM2 targeting small molecule Sob-AM2 improves cognition independent of Aβ plaque alteration in 5xFAD mice
Lucas Kuhnau, Gisselle A. Jimenez, Wyatt R. Hack, Samantha Varada, Noah Gladen-Kolarsky, Sunwoo Kim, Finch Klein, Tapasree Banerji, Joseph F. Quinn, Thomas S. Scanlan, Nora E. Gray
Sob-AM2 improves cognition in 5xFAD mice without altering Aβ plaque burden, suggesting TREM2-mediated microglial changes may underlie its effects.
bioRxiv · Aug 5, 2026 · PreprintNeuroscience